2/28/2023 0 Comments Roger the alien![]() He can pull any of his organs out through his skin without any ill effect to himself. He occasionally shoots green slime from his armpits. Aside from having a seemingly normal (though very large and shaped like his head) brain, his organs are unrecognizable and some have minds of their own his pancreas has teeth and once bit Hayley. ![]() Bizarre Alien Biology: Used to excellent effect.Big "NO!": Has had a few of his own, though not as many as Steve.Big Bad: At times, he's the main villain of a plot.Been There, Shaped History: In his lifetime he's responsible for creating disco in the 1970s (through a time paradox, admittedly), instigating the death of Biggie Smalls, creating Jar Jar Binks, inventing ecstasy in the 1990s, and turning Raven-Symone into an actress (after he kidnapped her from a park when she was a child).Apparently his persona carries on for quite a while before Roger notices extra bills on his credit card, at which point Roger tries to destroy this man's life. Then the stress of actually caring about someone causes Roger's mind to split into two - the persona he created, and himself. Becoming the Mask: He creates a new identity to seduce a shop-girl and allow him to steal a pair of gloves he likes.When Roger is laid up sick and Stan refuses to keep subbing for him, the town literally falls to ruin overnight. Many of whom are important figures in the city. He has so many of these serious personas running around at once that Roger actually makes up a fair percentage of Langley Falls population by himself. Most of them have lives that potentially stretch back decades. Barrier Maiden: Roger's personas are more often than not more than just a disguise he decided to wear that day.Bald of Evil: Roger is completely bald and a complete sociopath, although his personas do have wigs for hair.Yet whenever he auditions for a professional acting role, he is absolutely terrible at it. Bad Actor, Good Liar: Roger is a Manipulative Bastard who can easily deceive others with long-winded scams.Even Stan and Francine at their worst are nothing compared to Roger. Ax-Crazy: At his absolute worst moments, he frequently shows traits of this.Attention Whore: He's this almost all the time as part of being a Psychopathic Manchild.Anal Probing: Roger can learn all the knowledge and memories of a person by putting a finger up their bum.Anti-Hero: A Nominal Hero at best in his better moments.It's possible that Roger's species is hermaphroditic and capable of producing both male and female gametes. He also has the ability to impregnate others (both male and female humans) as seen in 'Deacon Stan, Jesus Man' and be impregnated himself as seen in 'Roger's Baby'. Ambiguous Gender Identity: Roger identifies as a man by default, though he is incredibly gender fluid, acting as masculine or as feminine as whatever disguise he's wearing calls for, and he's also able to grow breasts.The Alcoholic: He's often seen drinking.Always Camp: LOGO declared him the "Gayest Cartoon of All Time.".An Alien Named "Bob": An alien named Roger.In fact, the civilians are absolutely furious when they find out the emperor has been lying to them about the existence of true love, and join the slaves in a slave revolt. Though to be fair, the only members we actually see act like bastards are Roger, the Emperor and his guards. Aliens Are Bastards: His race needs to act like jerks, though it does depend on what person he is portraying with his costumes.If he's out in public, his blood is red, but whenever he's by himself or with the other Smiths, his blood is instead shown to be an exotic color like yellow, purple, blue, or green. Alien Among Us: Has been living on Earth since the mid-20th century, after being abandoned on Earth by his people as a disposable crash test dummy (they told him he was The Decider who would determine if humanity should be destroyed or not).This is actually one of his more positive personality traits. Alcohol-Induced Idiocy: He's extremely prone to it.As Hayley pointed out, if he didn't think they cared about him by that point, it was his problem, not theirs. The others actually get indignant because not only has this issue been dealt with before, but in that episode and others they had repeatedly gone out of their way to please his ever-insane needs and desires. It's even lampshaded in the episode "Great Space Roaster," where he reveals that he didn't really feel like a part of the Smith family, which is why he got insulted when they threw a comedy roast for his birthday (at his request). Aesop Amnesia: He's just as bad about this as Stan, if not worse. ![]()
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2/27/2023 0 Comments Hopefully yours edmond oklahoma![]() ![]() The staff at Stoneridge Animal Hospital is here to answer all those questions and more for you. At this point you’ve learned to pick your battles, right? So you pack Willy up and set her up with a very cute cat bed that she never uses and a catnip toy that she decidedly uses too much.īut now you might be thinking to yourself, “how do I avoid ending up like the Hendersons with a box full of kittens to unload?” When should I get Willy fixed? What are the options for the best spay and neuter clinic in Oklahoma City (because if something happens to Wilbur the kitten, you’re not sure if your kids will forgive you)? So of course your son picks out the runt of the litter and names that tiny little female cat Wilbur. ![]() There are a few strapping young options, and they’re looking mighty fine after the first few months with mom. So you trek the children next door to pick out the animal companion that will make your house a home for many years to come. And okay, maybe it helps that your next door neighbor just happens to have a litter of kittens that they have absolutely no idea what to do with. You can stave it off by having them volunteer at an animal shelter, cleaning up after the animals there and hopefully learning just how much responsibility it takes to own a pet full-time.īut at the end of the month, they still have their mind set on their first pet and you don’t have the heart to say no. That’s when the questions about getting a puppy or a kitten arise. You’ve just managed to avoid getting a rabbit or a chicken when your kids pleaded endlessly after the livestock showing at the state fair. You know how it goes as a parent in Oklahoma City. ![]() 2/27/2023 0 Comments Spike tv lip sync![]() Just two weeks in, the Spike TV series version of Jimmy Fallon’s Lip Sync Battle is looking like a legitimate hit, both on TV and online. Guess Tyson didn’t “push it” enough.Photo: Maya Robinson and Photo by SpikeTV He jumped and danced his heart out in leather leggings, but still couldn’t measure up. Mike Tyson took a different approach as he tried to retaliate with “Push It” by Salt-N-Pepa. “Sometimes you gotta get in touch with your feminine side,” he explained. He dazzled the audience by fervently twirling ribbons in the air as graceful ballerinas frolicked behind him. The Brooklyn-Nine-Nine actor chose Vanessa Carlton’s “Thousand Miles,” as a nod to fans of his White Chicks role. The two heavyweights didn’t wrestle for the title, instead they duked it out on the lip sync battlefield. She destroyed Emily like, well, a wrecking ball. Sporting a blonde pixie haircut, while wielding a sequined hammer, Hathway crushed it, blowing poor Blunt out of the water. But Hathaway literally came out swinging-on a giant wrecking ball no less-singing the Miley Cyrus hit. Blunt channeled Janis Joplin in her performance of “Piece of My Heart,” donning pink sunglasses and a fur coat. Speaking of Emily Blunt…she competed in a battle of her own against her former Devil Wears Prada costar. Krasinski may have stolen her girl, but Kendrick stole his victory. Kendrick took props to the next level and it payed off big time. Toward the end, she ripped open her jacket to reveal a photo of herself and Krasinski’s wife, Emily Blunt, as she crooned about how he stole her girl. Still, he ended up being no match for Kendrick, who soulfully serenaded the audience, with “Steal My Girl.” Krasinski kicked off the competition with supreme confidence, belting out a perfectly rehearsed version of “Bye Bye Bye,” while dancing like a marionette. It was the battle of the boy bands when Krasinski and Kendrick chose *NSYNC and One Direction, respectively, for their showdown. Sorry Fallon, you couldn’t even beat him at your own game. When host LL Cool J asked Johnson about his song selection, he proudly announced “Tay Tay,” and after Fallon tried to poke fun, he responded he would simply “Shake It Off.” Jimmy valiantly tried to counter with Harry Belafonte’s “Jump In The Line,” shimmying with his usual infectious enthusiasm, but still couldn’t manage to reach The Rock’s status. This battle was actually the very first one of the show, and though not as flashy as subsequent performances, the acts did not lack heart and soul. Dwayne ‘the Rock’ Johnson vs Jimmy Fallon ![]() ![]() Winner: It was actually a tie for the married duo who broke the rule and became the first championship couple of Lip Sync Battle.Ģ. Outfitted in a white tank and a backwards baseball cap, she gyrated to Ginuwine’s “Pony.”īut it was her hubby who ultimately stole the show, dressing head to toe as Beyonce while hip thrusting and hair flipping his way through an enthusiastic rendition of “Run The World (Girls)” before the real Beyonce sashayed her way down the stage to join him. Dewan-Tatum put up a good fight as she recreated her husband’s performance from hit film Magic Mike. Husband and wife reversed genders as they battled for the title of Lip Sync Champion. ![]() TV Insider selected a few of our favorite battles to showcase. As each pair of stars duel it out through song, only one can emerge victorious in the decked out champion belt. Of course, not all performances are equal. ![]() Related The Stars' Secret Weapon on 'Lip Sync Battle' Is Choreographer Danielle Flora ![]() ![]() Manage and adjust Survivor NPC to be more complex.Fixing bugs in the game will still be tested in many parts, of course, there must have many bugs followed.Manage performance and optimize the game for the better in the EA Version.World explore (forest, village, military camp, small town, hidden area).Character Survival Status Mechanics (Sickness, wound).Valheim is a brutal exploration and survival game for 1-10 players set in a. Ai (Bandit, Infected, Animalsm Allies Survivor) Includes iconic Bethesda games, new day one titles, and the EA Play on PC. more 819 Dislike Share Save Nightmare Monkey 106K subscribers 1K views New TheRussianBadger 1.4M views 7 days ago gameranx 6.Generator and electrical appliance mechanics.Time Mechanics (passing time, sleeping, time is accelerated when doing something that takes time).Keep your animals alive against all odds, such as hungry predators, climate change and spreading sickness. Shape your own species of cat/fox/bear/dog-like animals based on real genetics. Dynamic fog weather and Day-Night cycle Niche - a genetics survival game is a fresh blend of turn-based strategy and simulation combined with roguelike elements.People who are infected and mutated will be able to come out outdoors at night or when there is no sunshine that means they can also hunt players while the fog is covered. ![]() Left to Survive is a fast paced survival shooter, in which. The dense mist environment is accompanied by certain events, such as the infected people come around to find preys. If you download Left to Survive, youll have two major threats to face, zombies and human survivors. Players will experience dense mist that can happen at any time. Raft Survival Hardtime Island Escape Life Simulator 3D: Hero Fighting Evolution Adventure Craft Games Free For kids. Players can also help other survivors and get the survivors to join your camp. Players will be immune from the virus outbreak and must survive the situation by hoarding food, finding shelter and protecting yourself from wildlife, bandits, and infected. ![]() 2/27/2023 0 Comments Olive and finch cherry creek![]() That's what we believe it takes to hand-craft recipes that are wholesome and full of flavor. Our meats are roasted and seasoned by our chefs-all under our very own roof. We've spruced up a selection of classic recipes along with a variety of creative dishes all made with our love for savory food made fresh.We keep our kitchen stocked with fresh baked breads, sauces made by hand, and the freshest produce available. Order delivery or pickup from Olive & Finch Eatery in Denver View Olive & Finch Eaterys October 2022 deals and menus. We know a home-cooked meal or full dining-out experience is not always an option, but we also know the quality of your food should never be compromised, that's why we're here. We will schedule a stage with you as part of the interview process.Ībout Olive and Finch: Our focus is scratch-made and wholesome food delectably made to order. This position is guaranteed $18.00/hour but is part of a tip pool and tip rate can increase week by week. Must follow proper food safety guidelines when switching between tasks. ![]() Shift require prepping for the next service. (10 pm-5 pm) - Able to multi-task between orders while working a busy salad and/or flattop station (prepping, restocking and cleaning) throughout shift. ![]() ![]() Line Cook (Full and Part Time) - Full availability or 4 10-hour Shifts (Tuesday-Thursday & Sunday) required. We specialize in "scratch made, chef-driven food"! We are looking for career-minded individuals with BIG personalities! We offer competitive pay, meal discounts, benefits (for full-time team members), amazing promotional opportunities, great tasting food, and a chance to join an awesome team! Keep an eye out for an Olive & Finch coming close to you, particularly if you live Downtown.Olive and Finch, an award winning fine casual concept is currently hiring for several positions at our Cherry Creek (1st Ave) location. Speaking of dietary restrictions, the restaurant is not only conscious but well-prepared to handle vegetarian and vegan diners, as well as those suffering from celiac disease and other allergies.īreakfast, lunch, and dinner are served daily. At lunch and dinner five main plates give diners a selection they didn't have at the first Olive & Finch: Sous-vide prepared steak, chicken, salmon, and pork, with side dishes and salads, plus a seasonal pasta option for the meat-free crowd. Salads and soups, as well as four flatbreads provide more variety. There are 16 choices just on the sandwich menu for lunch and the Fettster, which features house-cured salmon, is a must. The breakfast menu has highlights like the shakshuka, the quinoa pancakes with lemon blueberry compote, and the open faced croque madame. There are still fresh pressed juices, a small wine, beer, and cocktail program, and a full coffee menu, now featuring Pablo's beans but soon-to-change to the highly coveted Intelligentsia beans. It is casual but not lacking in attention to detail, it is approachable but not dumbed down. The core of Olive & Finch remained the same: Provide thoughtful food, made with high quality ingredients, at a great price, in an environment that is reminiscent of French traiteurs. It is bright and airy, with lots of seating, a wide array of pastries, some beautiful cakes to take home, a catering kitchen, and a way to create main courses for dinner that rival some of our favorite restaurants in taste and presentation. The space in Cherry Creek is much larger. Those assumptions have been removed by experience. ![]() Three years ago, when Nguyen launched the original in Uptown, she assumed some things: That guests would grab and go mostly, that they would order more salads and less pastries, that they would grab a cup of coffee and a juice and go on with their day. Olive & Finch is now an amenity to Cherry Creek because the eatery and café, which serves breakfast, lunch, and dinner is vastly improved. Chef Mary Nguyen has both the razor sharp focus and the nimbleness to take a successful concept and improve it based on the demands of the guests. ![]() ![]() System Requirements for Microsoft Office 2019 for Mac v16.39 Microsoft Word download free. Software File Name: Office-2019-Mac-16.39.zip.Technical Details of Microsoft Office 2019 for Mac v16.39 Comes with a simple and clean interface that enables you to focus on your work.Helps users to work in a teamwork and makes documents available to all team.Gives you complete control to add images, links, set font size, color and much more.Empowers you to create spreadsheets, presentations and rich-media documents.A perfect suite developed to fulfill the needs of various users in digital documents.Features of Microsoft Office 2019 for Mac v16.39 Put simply, MS Office 2019 for macOS X is the only program in industry that offers each and everything for creating rich-media and highly professional documents. At the end, it provides Outlook, a program that helps users to manage email, calendar, contacts and tasks in an easy way. Similarly, its OneNote allows customers to keep notes, ideas, web pages, photos, audio and clips in the same place. MS PowerPoint is specially used for making lovely presentations as it allows users to add animations, videos, transitions and different types of heading and fonts. To make cool and jaw-dropping presentations, it contains MS PowerPoint. In other words, this is excellent software.They offer you many new writing styles, which make your writing more attractive. If you looking on the internet an Microsoft Word for Mac So, you come to the right place now a day shares with you an amazing application its most popular and used the able product for Microsoft word for Mac full version Design for documents formatting tools, you can write a document and edit online shares and save online Web browser.Moreover, you can also make outstanding slides with the new thesis of PowerPoint.Where you can also get easy access to all tools, which require just a single click.Furthermore, it also hides your identity while you are working on this software.It also provides you with more privacy techniques, which help to save your data from all snooper or hackers.However, you can also save your data on the office cloud.So, you can deal with a better way with your customer. Moreover, it gives more outlook helps.Where you can also save your data up to 50GB.While working with the latest office planner. Furthermore, you can organize all of your routines. ![]() ![]() They give you many toolbars, which fulfill all of your needs.However, you can share your online work directly with your employees or your colleague.They provide you easy to user interface, which includes more than 120 languages.Moreover, this software is fully compatible with all the latest devices.This software provides you 50GB mailbox storage for a capacity of hosting mail.There are many more essential features where it provides you best understanding. ![]() 2/27/2023 0 Comments Apg performance![]() ![]() ![]() By doing so, we hope more enthusiast who love performance and lifestyle can join APG and share our joy of motor sports at a equitable price. Mary Hogan, managing director at APG Asset Management, joined for a video interview at REITWorld 2014: NAREITs Annual Convention for All Things. We attach great importance to quality and customer service to our products, and we actively expose our products on the track to prove our quality and high performance. The company has a fifty day simple moving average of 15.08 and a two-hundred day simple moving average of 16.24. But, since we are a new brand, it actually gives us more flexibility on what we strive for. ![]() We know that we cannot compare with them in volume at the current moment since they’ve been in the market for so long. We’ve done the research and development to provide kits that fit an extremely wide-variety of applications.ĪPG is a newly founded brand. However, this doesn’t mean our products are overpriced – in fact, for a comprehensive braking package, they are much more competitively priced than the alternatives.Ĭurrently our BBK kit line up covers from European car, American Muscles to JDM enthusiast community. Our products are designed and researched on an on-going basis in our own facilities, rather than turning a high-safety product into a commodity marketed price point product. The focus of APG Performance will always be on quality, not on price. Whether you need to fortify your company's supply chain or get new outlets to reach your customers, APG's companies and brands have you and your business covered. Our Missionįrom race track to public street, our goal is to provide the highest quality solution to all kinds of driving enthusiasts.The core idea of APG is to bring “a perfect gear” for all the users with a perfect guidance on the road.ĪPG Performance forged brake dedicates to produce quality modifications for all kinds of driving machines. that Advantage is a global goldmine of performance ideas, resources, world-class solutions, and personal partnerships that last. APG's companies and partners cover wholesale, E-commerce, and manufacturing, giving a complete vertically integrated enterprise that can meet essentially any need. The app, launched in 2018, is tailor-made for business aviation, and focused on single-pilot operators and small flight departments. We hope this is not just a brand but an attitude towards life – pursuing your ambitions instead of settling. Aircraft Performance Group (APG) announced the inclusion of graphical engine-out features to its iPreflight Genesis app, as well as executive appointments and new sales agreements at NBAA-BACE 2019. After discussing with several Japanese friends who are keen on motorsport, we decided to design our own brand APG Performance. But, wanted an alternative to the companies that existed at the time, as we felt that their product costs were very exaggerated. APG Brakes 60 0 : 2.84, 117.9 ft Stock OEM Brakes 60 0 : 3.03, 122.3 ft Value : 2k+ brake kits arent usually associated with being budget friendly, but these are about 1/3 to 1/2 the costs of competing BBKs out in the market today, and comes with all necessary SS lines and brake pads as well. We demanded high quality for safety and braking in all aspects of motor sport. APG Performance was founded in Japan in 2014. ![]() 2/27/2023 0 Comments Chromium sources![]() ![]() According to NTP, there is sufficient evidence for carcinogenicity in experimental animals for the following hexavalent chromium compounds calcium chromate, chromium trioxide, lead chromate, strontium chromate,and zinc chromate. Respiratory symptoms may include coughing and wheezing, shortness of breath, and nasal itch.Ĭarcinogenicity- Chromium and most trivalent chromium compounds have been listed by the National Toxicology Program (NTP) as having inadequate evidence for carcinogenicity in experimental animals. Inhalation of hexavalent chromium compounds can result in ulceration and perforation of the mucous membranes of the nasal septum, irritation of the pharynx and larynx, asthmatic bronchitis, bronchospasms and edema. Adverse effects of the hexavalent form on the skin may include ulcerations, dermatitis, and allergic skin reactions. The metal form (chromium as it exists in this product) is of low toxicity. The health hazards associated with exposure to chromium are dependent on its oxidation state. Other health problems that are caused by chromium(VI) are: After breathing it in chromium(VI) can cause nose irritations and nosebleeds. When it is a compound in leather products, it can cause allergic reactions, such as skin rash. ![]() People who smoke tobacco also have a higher chance of exposure to chromium.Ĭhromium(VI) is known to cause various health effects. But the uptake of too much chromium(III) can cause health effects as well, for instance skin rashes.Ĭhromium(VI) is a danger to human health, mainly for people who work in the steel and textile industry. When food in stores in steel tanks or cans chromium concentrations may rise.Ĭhromium(III) is an essential nutrient for humans and shortages may cause heart conditions, disruptions of metabolisms and diabetes. Various ways of food preparation and storage may alter the chromium contents of food. For most people eating food that contains chromium(III) is the main route of chromium uptake, as chromium(III) occurs naturally in many vegetables, fruits, meats, yeasts and grains. In drinking water the level of chromium is usually low as well, but contaminated well water may contain the dangerous chromium(IV) hexavalent chromium. The level of chromium in air and water is generally low. ![]() People can be exposed to chromium through breathing, eating or drinking and through skin contact with chromium or chromium compounds. Reserves are hestimated to be of the order of 1 billion tonnes with unexploited deposits in Greenland, Canada e USA. A total of 14 million tonnes of chromite ore is extracted. Chromium ores are mined today in South Africa, Zimbabwe, Finland, India, Kazakihstan and the Philippines. Chromium (IV) oxide (CrO 2) is used to manufacture magnetic tape.Ĭhromium is mined as chromite (FeCr 2O 4) ore. Chromium is used in metallurgy to impart corrosion resistance and a shiny finish as dyes and paints, its salts colour glass an emerald green and it is used to produce synthetic rubies as a catalyst in dyeing and in the tanning of leather to make molds for the firing of bricks. Chromium plating was once widely used to give steel a polished silvery mirror coating. ApplicationsĬhromium main uses are in alloys such as stainless steel, in chrome plating and in metal ceramics. Chromium is unstable in oxygen, it immediately produces a thin oxide layer that is impermeable to oxygen and protects the metal below. It does not tarnish in air, when heated it borns and forms the green chromic oxide. Its colour is silver-gray and it can be highly polished. Separation and Concentration Purification RequestĬhromium - Cr Chemical properties of chromium - Health effects of chromium - Environmental effects of chromiumĬhromium is a lustrous, brittle, hard metal.Plant Inspection & Process Optimalisation. ![]() 2/27/2023 0 Comments Website host free privacy guard![]() ![]() Content may contain your voice and image, depending on the account owner’s settings, what you choose to share, your settings, and what you do on Zoom products and services. Content and Context from Meetings, Webinars, Messaging, and Other Collaborative Features: Content generated in meetings, webinars, or messages that are hosted on Zoom products and services, which may include audio, video, in-meeting messages, in-meeting and out-of-meeting whiteboards, chat messaging content, transcriptions, transcript edits and recommendations, written feedback, responses to polls and Q&A, and files, as well as related context, such as invitation details, meeting or chat name, or meeting agenda.Device Information: Information about the computers, phones, and other devices used when interacting with Zoom products and services, which may include information about the speakers, microphone, camera, OS version, hard disk ID, PC name, MAC address, IP address (which may be used to infer general location at a city or country level), device attributes (like operating system version and battery level), WiFi information, and other device information (like Bluetooth signals).Registration Information: Information provided when registering for a Zoom meeting, webinar, Zoom Room, or recording, which may include name and contact information, responses to registration questions, and other registration information requested by the host.Settings: Information associated with the preferences and settings on a Zoom account or user profile, which may include audio and video settings, recording file location, screen sharing settings, and other settings and configuration information.Contact Information: Contact information added by accounts and/or their users to create contact lists on Zoom products and services, which may include contact information a user integrates from a third-party app, or provided by users to process referral invitations.Profile and Participant Information: Information associated with the Zoom profile of a user who uses Zoom products and services under a licensed account or that is provided by an unlicensed participant joining a meeting, which may include name, display name, picture, email address, phone number, job information, stated locale, user ID, or other information provided by the user and/or their account owner.Account Information: Information associated with an account that licenses Zoom products and services, which may include administrator name, contact information, account ID, billing and transaction information, and account plan information.We may collect, or process on behalf of our customers, the following categories of personal data when you use or interact with Zoom products and services: Personal data is any information from or about an identified or identifiable person, including information that Zoom can associate with an individual person. European Data Protection Specific Information.Who Can See, Share, and Process My Personal Data When I Join Meetings and Use Other Zoom Products and Services?. ![]() 2/27/2023 0 Comments Nfkb promotee![]() They also discussed the effects of glucocorticoids on NF-kappa-B and the therapeutic implications. They tabulated the stimuli that activate NF-kappa-B and the proteins regulated by this transcription factor. (1998), these results indicated that p105 is not the precursor of p50 and revealed a novel mechanism of gene regulation that ensures the balanced production and independent function of the p50 and p105 proteins.īarnes and Karin (1997) reviewed the role of NF-kappa-B in chronic inflammatory diseases. (1998) demonstrated that the p50 protein product of NFKB1 is generated by a unique cotranslational processing event involving the 26S proteasome (see 602706), whereas cotranslational folding of sequences near the C terminus of p50 abrogates proteasome processing and leads to production of p105, the other protein product of NFKB1. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T R is an A or G purine and Y is a C or T pyrimidine). Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, 600664, or IKBKB, 603258) marks them for destruction via the ubiquitination pathway (see 603482), thereby allowing activation of the NF-kappa-B complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, 164008 or NFKBIB, 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. ![]() |
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